A personal squick is any games that include a mandatory element that I'm desperately trying to escape when living real life.
So time passage is a huge one. I'm severely stressed out by time passing in a game where I don't have the luxury of getting things done in my own pace. I absolutely cannot play Animal Crossing because of that, but also a few titles that I'd otherwise love are near unplayable to me.
In a more minor sense, I do not like games with day/night rotations in general.